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Updated: May 8, 2026

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
Published on: July 7, 2023
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis
Alisdair McNeill1, Ruey-Meei Wu, Kai-Yuan Tzen
1Department of Clinical Neurosciences, Institute of Neurology, University College London, London, United Kingdom.
Objectives:
To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.
Methods:
A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.
Results:
Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.
Conclusions:
The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
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