Related Experiment Video

Updated: May 8, 2026

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer

Yu Zhao1, Chenglong Li, Ming Wang

  • 1Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Plos One
|August 13, 2013
PubMed

Insights

MicroRNA miR-202-3p acts as a tumor suppressor in gastric cancer by inhibiting cancer cell growth and promoting apoptosis. It targets Gli1, a key factor in gastric cancer progression, highlighting its therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cancer development and progression.
  • Gastric cancer remains a significant global health challenge with complex underlying molecular mechanisms.

Purpose of the Study:

  • To investigate the role of miR-202-3p in gastric cancer.
  • To identify the molecular targets and mechanisms through which miR-202-3p exerts its effects in gastric cancer.

Main Methods:

  • Analysis of miR-202-3p expression levels in gastric cancer tissues.
  • Overexpression of miR-202-3p in gastric cancer cell lines (MKN-28, BGC-823) and in vivo models.
  • Assessment of cell proliferation, apoptosis, and target gene expression (Gli1, γ-catenin, BCL-2).

Main Results:

  • miR-202-3p was significantly downregulated in gastric cancer tissues.
  • Overexpression of miR-202-3p suppressed gastric cancer cell proliferation and induced apoptosis in vitro and in vivo.
  • Gli1 was identified as a direct target of miR-202-3p, mediating its tumor-suppressive effects.
  • miR-202-3p also inhibited the expression of γ-catenin and BCL-2.

Conclusions:

  • miR-202-3p functions as a novel tumor suppressor in gastric cancer.
  • The anti-tumor activity of miR-202-3p is mediated through the direct targeting and inhibition of Gli1.
  • miR-202-3p represents a potential therapeutic target for gastric cancer treatment.

More Related Videos

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...