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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Stromal Cell Isolation From Hematopoietic Organs
05:27

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Published on: January 26, 2024

HSC-explorer: a curated database for hematopoietic stem cells.

Corinna Montrone1, Konstantinos D Kokkaliaris, Dirk Loeffler

  • 1Institute for Bioinformatics and Systems Biology (IBIS), Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Plos One
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

HSC-Explorer is a new database detailing early hematopoiesis (blood formation). It offers structured data on over 7000 interactions, aiding researchers in understanding blood stem cell biology.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Cell Biology

Background:

  • Hematopoiesis is a complex process involving numerous molecular and cellular interactions.
  • Existing resources may lack comprehensive, integrated data on early hematopoiesis.
  • Understanding hematopoietic stem cell (HSC) maintenance is crucial for regenerative medicine.

Purpose of the Study:

  • To develop HSC-Explorer, an integrative database for early hematopoiesis research.
  • To provide accessible, structured information on molecular and cellular interactions in hematopoiesis.
  • To facilitate the analysis and visualization of complex biological networks.

Main Methods:

  • Manual curation of scientific literature by expert annotators.
  • Integration of experimentally validated interactions (molecules, bioprocesses, environmental factors).
  • Development of visualization interfaces and use of established vocabularies.

Main Results:

  • HSC-Explorer contains over 7000 experimentally validated interactions.
  • Data includes context information (model organisms, experimental methods) for reliability assessment.
  • Predefined datasets offer insights into stem cell behavior, niche, and signaling.

Conclusions:

  • HSC-Explorer provides a valuable, publicly available resource for hematopoiesis research.
  • The database enables rapid access to complex interaction networks.
  • It supports bioinformatics applications and enhances understanding of hematopoietic stem cell maintenance.