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Updated: May 8, 2026

Rapid Generation of Primary Murine Melanocyte and Fibroblast Cultures
Published on: June 26, 2019
The contribution of melanocytes to pathological scar formation during wound healing
Fu-Lei Gao1, Rong Jin, Lu Zhang
1Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China 200011.
Abstract:
Both hypertrophic scars and keloid scars are caused by abnormal wound healing, the key feature of which is excess collagen fiber secretion by fibroblasts. Many different factors could affect the process of hypertrophic scar and keloid formation, but most have not been identified to date. We assume that, during wound healing, melanocytes from the stratum basale contact or interact with fibroblasts from the dermal layers after the basal membrane is damaged, which in turn facilitates fibroblast proliferation and the secretion and deposition of collagen. This plays a significant role in the generation of hypertrophic scars and keloids.
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