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Published on: June 30, 2023

Behçet's Disease and Intracardiac Thrombosis: A Report of Three Cases

Nurşen Düzgün1, Orhan Küçükşahin, Kayhan Çetin Atasoy

  • 1Department of Internal Medicine-Rheumatology, Ankara University, Faculty of Medicine, Akademik Yerleşke, Sıhhıye, 06100 Ankara, Turkey.

Case Reports in Rheumatology
|August 13, 2013
PubMed

Insights

Behçet

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Immunology

Background:

  • Behçet's disease is a rare multisystemic inflammatory disorder.
  • Intracardiac thrombus and pulmonary vascular involvement are uncommon manifestations.
  • Budd-Chiari syndrome can be a co-occurring condition.

Purpose of the Study:

  • To report on three cases of Behçet's disease with intracardiac thrombus and pulmonary vascular disease.
  • To evaluate the efficacy of immunosuppressive therapy in managing these cardiovascular complications.

Main Methods:

  • Case series presentation of three patients diagnosed with Behçet's disease.
  • Treatment involved first-line therapy with corticosteroids and monthly intravenous cyclophosphamide.
  • Clinical outcomes, including thrombus resolution and disease recurrence, were monitored.

Main Results:

  • All three patients achieved remission without recurrence following immunosuppressive treatment.
  • Intracardiac thrombi resolved, and pulmonary vascular thromboses regressed.
  • One patient with Budd-Chiari syndrome also showed positive response to therapy.

Conclusions:

  • Combined corticosteroid and cyclophosphamide therapy is effective for intracardiac thrombus and pulmonary vascular involvement in Behçet's disease.
  • Behçet's disease should be considered in the differential diagnosis of intracardiac masses, particularly in endemic populations.
  • Early diagnosis and aggressive immunosuppression can prevent disease progression and recurrence.

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