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Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

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Related Experiment Video

Updated: May 8, 2026

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

Understanding the dengue viruses and progress towards their control.

Rosmari Rodriguez-Roche1, Ernest A Gould

  • 1Pedro Kouri Tropical Medicine Institute, WHO/PAHO Collaborating Centre for the Study of Dengue and Its Vector, Havana, Cuba. rosmari@ipk.sld.cu

Biomed Research International
|August 13, 2013
PubMed
Summary

Dengue virus infections are rising globally, causing not only classic symptoms but also severe neurological complications. This review highlights dengue pathogenesis and control strategies for this tropical disease.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Pathogenesis

Background:

  • Dengue virus (four serotypes) traditionally linked to fever, rash, hemorrhagic fever, and shock syndrome.
  • Increasing global incidence of human infections.
  • Recognition of neurological and other severe clinical complications, including sequelae and fatalities.

Purpose of the Study:

  • To review dengue virus pathogenesis.
  • To highlight clinical complications beyond traditional symptoms.
  • To examine current dengue control efforts.

Main Methods:

  • Literature review focusing on dengue virus pathogenesis.
  • Analysis of clinical manifestations and complications.
  • Examination of disease control strategies.

Main Results:

  • Dengue virus infections present a broader spectrum of clinical manifestations than previously understood.
  • Neurological and other severe complications are significant features of dengue pathogenesis.
  • Ongoing efforts aim to control the global spread of dengue.

Conclusions:

  • Dengue virus pathogenesis is complex, leading to diverse and severe clinical outcomes.
  • Understanding these complexities is crucial for effective disease control.
  • Continued research and public health interventions are necessary to combat dengue.