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Related Experiment Video

Updated: May 8, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Paraneoplastic neurological syndromes.

F Leypoldt¹, K-P Wandinger

¹Department of Neurology, University Medical-Center Hamburg-Eppendorf, Hamburg; Josep Dalmau's Laboratory, Catalan Institution for Research and Advanced Studies (ICREA), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

Clinical and Experimental Immunology

|August 14, 2013

Summary

This summary is machine-generated.

Paraneoplastic neurological syndromes involve immune attacks on the nervous system. Recent discoveries of treatable subgroups and associated autoantibodies are improving patient outcomes and guiding therapy.

Keywords:

anti-NMDA receptor encephalitis limbic encephalitis paraneoplastic antibodies paraneoplastic syndromes

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Area of Science:

Neurology
Immunology
Oncology

Background:

Paraneoplastic neurological syndromes (PNS) are immune responses targeting the nervous system due to cancer.
Despite being known for decades, recent advances have identified new subgroups with favorable responses to immunotherapy.
Understanding these syndromes and their associated autoantibodies is crucial for effective treatment decisions.

Purpose of the Study:

To review current knowledge and recent developments in paraneoplastic neurological syndromes.
To clarify the classification, pathophysiology, and treatment of these complex conditions.
To aid clinicians and researchers in navigating the expanding landscape of PNS and associated autoantibodies.

Main Methods:

Literature review of recent studies on paraneoplastic neurological syndromes.
Synthesis of information on classification, pathophysiology, and treatment strategies.
Focus on newly identified subgroups and autoantibodies.

Main Results:

Identification of specific subgroups of paraneoplastic encephalitis with significant response to immunotherapy.
Association of distinct autoantibodies with particular neurological syndromes and tumor types.
Improved understanding of the pathophysiology linking cancer and neurological autoimmunity.

Conclusions:

New autoantibodies and syndromes in PNS require updated knowledge for accurate diagnosis and management.
Timely identification and characterization of PNS are essential for initiating appropriate immunotherapy.
Continued research into PNS pathophysiology and treatment holds promise for better patient prognoses.