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[Different combination of drugs regarding the damage on organs targeting salt sensitivity or non-salt-sensitive

Qi Wu1, Xiao-juan Qin, Yan-tian Tang

  • 1Department of Internal Medicine-Cardiovascular, Beilun District People's Hospital of Ningbo, Ningbo 315800, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|August 14, 2013
PubMed
Abstract

Insights

For salt-sensitive hypertension, perindopril with indapamide improved organ damage markers. For non-salt-sensitive hypertension, perindopril with felodipine was more suitable, showing distinct treatment efficacies for different hypertension types.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Endocrinology

Context:

  • Hypertension management requires tailored therapeutic strategies.
  • Salt sensitivity influences organ damage in hypertensive patients.
  • Optimizing drug combinations is crucial for effective hypertension treatment.

Purpose:

  • To investigate organ damage in salt-sensitive (SS) versus non-salt-sensitive (NSS) hypertension.
  • To evaluate the efficacy of two drug combinations: felodipine/perindopril and indapamide/perindopril.
  • To determine the optimal drug selection based on salt sensitivity in hypertensive patients.

Summary:

  • 120 hypertensive patients (60 SS, 60 NSS) were treated for 12 weeks with either felodipine/perindopril or indapamide/perindopril.
  • Treatment effects on blood pressure, insulin resistance, and organ damage markers (e.g., left ventricular mass index, urinary albumin) were assessed.
  • Indapamide/perindopril showed significant improvements in SS patients, while felodipine/perindopril was more effective in NSS patients.

Impact:

  • Provides evidence for personalized hypertension treatment based on salt sensitivity.
  • Highlights differential efficacy of drug combinations in managing target organ damage.
  • Informs clinical decision-making for selecting antihypertensive therapies in diverse hypertensive populations.

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