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Updated: May 8, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
Infection following simultaneous bilateral total knee arthroplasty
Lazaros A Poultsides1, Stavros G Memtsoudis, Theofanis Vasilakakos
1Department of Orthopaedic Surgery, Division of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York.
Simultaneous bilateral total knee arthroplasty (SBTKA) shows lower infection rates than staged or unilateral total knee arthroplasty (UTKA). SBTKA is safe and effective, offering an advantage in reducing infectious complications.
Area of Science:
- Orthopedic Surgery
- Infectious Disease Epidemiology
- Arthroplasty Research
Background:
- Total knee arthroplasty (TKA) is a common procedure for end-stage knee arthritis.
- Different surgical approaches, including simultaneous bilateral total knee arthroplasty (SBTKA), staged bilateral total knee arthroplasty, and unilateral total knee arthroplasty (UTKA), exist.
- Understanding infection rates associated with each approach is crucial for patient outcomes.
Purpose of the Study:
- To compare infection rates and characteristics among patients undergoing SBTKA, staged TKA, and UTKA.
- To evaluate the safety and efficacy of SBTKA concerning infectious complications.
- To identify risk factors for infection following different TKA approaches.
Main Methods:
- Retrospective comparison of 17,837 patients undergoing TKA between 2000 and 2009.
- Categorization into SBTKA (16%), staged (6%), and UTKA (78%) groups.
- Analysis of demographics, clinical characteristics, and infection details, including in-hospital, late, and superficial infections.
Main Results:
- SBTKA demonstrated a significantly lower overall infection rate (0.57%) compared to staged (1.39%) and UTKA (1.1%).
- In-hospital and superficial infection rates were significantly lower in the SBTKA group.
- Regression analysis indicated UTKA patients were 2.5 times, and staged patients 3.4 times more likely to develop in-hospital infections compared to SBTKA.
Conclusions:
- SBTKA offers an advantage over staged and unilateral approaches regarding infectious complications.
- SBTKA maintains a comparable safety profile to unilateral TKA concerning infection risk.
- Surgical approach in TKA significantly impacts in-hospital infection rates, with SBTKA showing a protective effect.
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