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Updated: May 8, 2026

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents
Lei Zhang1, Xiaoyun Chai, Baogang Wang
1Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Abstract:
A series of 11,12-cyclic carbonate azithromycin-4″-O-carbamoyl glycosyl derivatives were designed, synthesized, and evaluated as antibacterial agents to search for target compounds with excellent activity. The results of preliminary antibacterial tests against eight strains in vitro revealed that all of the title compounds exhibited improved activities with broad spectrum compared with the parent compound. The glycosylated side chains may be the pharmacophores responsible for the improved activity.
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