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[Effect of calcium antagonists on the Ca2(+) paradox]
N Tribulová1, J Slezák, T Ravingerová
1Ustavu experimentálnej chirurgie CFV SAV v Bratislave.
Bratislavske Lekarske Listy
|June 1, 1990
Abstract:
The model of calcium paradox was used to test the effect of the calcium entry blocker Diltiazem (concentration 4.0 mumol.l-1) and of the calmodulin inhibitor Trifluoroperazin (concentration 1.0 mumol.l-1). Application of each preparation resulted in improved cardiac function manifested by restoration of the electrical and contractile activity and by increased coronary flow. Both Diltiazem and Trifluoroperazin exerted a protective effect on the preservation of enzymatic activities and of ultrastructure in conditions of impaired calcium homeostasis.