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Related Concept Videos

Parkinson Disease l: Introduction01:24

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Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
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Related Experiment Video

Updated: May 8, 2026

Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
11:31

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Published on: September 18, 2013

LRRK2: cause, risk, and mechanism.

Coro Paisán-Ruiz1, Patrick A Lewis, Andrew B Singleton

  • 1Department of Neurology, Psychiatry, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, NY, USA.

Journal of Parkinson'S Disease
|August 14, 2013
PubMed
Summary

Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene cause Parkinson's disease. Research highlights LRRK2's role in disease development and explores its kinase activity as a potential therapeutic target.

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Last Updated: May 8, 2026

Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
11:31

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Published on: September 18, 2013

Assaying the Kinase Activity of LRRK2 in vitro
06:09

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Published on: January 18, 2012

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

Area of Science:

  • Genetics
  • Neuroscience
  • Molecular Biology

Background:

  • Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene were identified as a cause of Parkinson's disease in 2004.
  • A specific LRRK2 mutation is a common cause of Parkinson's disease across diverse populations.
  • Genetic studies reveal various LRRK2 gene associations with Parkinson's disease risk, including common alleles affecting protein sequence and expression.

Purpose of the Study:

  • To review the genetic links between LRRK2 and Parkinson's disease.
  • To summarize functional characterization of LRRK2 and its mutations.
  • To discuss the potential of LRRK2 kinase activity as a therapeutic target.

Main Methods:

  • Genetic investigation of LRRK2.
  • Functional characterization of LRRK2 mutations.
  • Review of existing research on LRRK2 and Parkinson's disease.

Main Results:

  • LRRK2 mutations are a significant genetic cause of Parkinson's disease.
  • Common LRRK2 alleles influence Parkinson's disease risk through protein alterations and expression changes.
  • Kinase activity of LRRK2 is a focus for therapeutic strategies.

Conclusions:

  • Significant progress has been made in understanding LRRK2's role in Parkinson's disease.
  • LRRK2 kinase activity is a promising, though not yet confirmed, therapeutic target.
  • Future research in LRRK2 is expected to yield further insights and potential treatments for Parkinson's disease.