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Updated: May 8, 2026
09:10
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
Omics technologies and the study of human ageing
Ana M Valdes1, Daniel Glass, Tim D Spector
11] Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK. [2] Academic Rheumatology, University of Nottingham, Nottingham NG5 1PB, UK.
Nature Reviews. Genetics
|August 14, 2013
Summary
Normal aging brings physiological changes, varying individually. Molecular profiling using high-throughput omics technologies reveals biological pathways affected by aging, aiding disease prevention and treatment strategies.
Area of Science:
- Gerontology and Molecular Biology
- Biogerontology
- Human Aging Research
Background:
- Aging is a natural process with diverse physiological changes across organ systems.
- The rate and extent of age-related changes differ significantly among individuals.
- Understanding molecular changes during aging is crucial for healthspan and disease management.
Purpose of the Study:
- To investigate the molecular profiling of age-related physiological changes in humans.
- To explore the utility of high-throughput omics technologies in aging research.
- To identify biological pathways that are altered with increasing age.
Main Methods:
- Utilizing advanced high-throughput 'omics' technologies, including genomics, metabolomics, metagenomics, and transcriptomics.
- Conducting molecular profiling studies on human aging cohorts.
- Analyzing data to identify age-associated molecular alterations and pathway changes.
Main Results:
- High-throughput omics technologies enable detailed molecular profiling of aging.
- These technologies reveal significant changes in biological pathways with increasing age.
- Molecular profiling provides insights into the mechanisms underlying individual aging variations.
Conclusions:
- Molecular profiling of aging is a key area of research with significant implications.
- Omics technologies are powerful tools for dissecting the complexities of the aging process.
- Understanding age-related molecular changes can inform strategies for disease prevention and treatment.
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