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Updated: May 8, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
Published on: January 11, 2011
Portable, miniaturized, fibre delivered, multimodal CARS exoscope
Brett Smith1, Majid Naji, Sangeeta Murugkar
1School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward, PO Box450 Stn A, Ottawa, Ontario K1N 6N5, Canada. bsmit021@uottawa.ca
Abstract:
We demonstrate for the first time, a portable multimodal coherent anti-Stokes Raman scattering microscope (exoscope) for minimally invasive in-vivo imaging of tissues. This device is based around a micro-electromechanical system scanning mirror and miniaturized optics with light delivery accomplished by a photonic crystal fibre. A single Ti:sapphire femtosecond pulsed laser is used as the light source to produce CARS, two photon excitation fluorescence and second harmonic generation images. The high resolution and distortion-free images obtained from various resolution and bio-samples, particularly in backward direction (epi) successfully demonstrate proof of concept, and pave the path towards future non or minimally-invasive in vivo imaging.
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