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Updated: May 8, 2026

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
Published on: December 12, 2025
Pathogen profile in men with inflammation of paraurethral glands
Wenge Fan1, Qingsong Zhang, Tingwang Jiang
1Department of Dermatology, First People's Hospital of Changshu City, Changshu Hospital, Affiliated to Soochow University, , Changshu, Jiangsu Province, P R China.
Objective:
To investigate the pathogen profile in men with inflammation of the paraurethral glands.
Methods:
We enrolled 40 patients with first-onset, drug-naive inflammation of the paraurethral glands. Discharge from the lesions was collected for Gram staining. Microscopy was performed for screening for trichomonads and detecting Gram-negative intracellular diplococci within phagocytes. Cultures for detection of Neisseria gonorrhoeae, Ureaplasma urealyticum and other bacteria, and Chlamydia-trachomatis-associated antigens were performed. PCR was conducted for herpes simplex virus type 1 or 2.
Results:
From these 40 patients, there were nine microbial species, which included Gram-negative bacteria (23 cases, 54.8%), Gram-positive bacteria (15 cases, 35.7%) and other pathogens (4 cases, 9.5%). The top three pathogens were gonococci (38.1%), Staphylococcus aureus (16.7%) and Escherichia coli (14.3%).
Conclusions:
Inflammation of paraurethral glands in men may be caused by a variety of pathogens and not just by gonococcal infection.
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