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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Orbscan topography in primary open-angle glaucoma.

Esther Arranz-Marquez1, Gema Bolivar, David P Piñero

  • 1*MD, PhD †PhD Rey Juan Carlos Hospital, Móstoles, Madrid, Spain (EA-M); Novovision, Madrid, Spain (EA-M, MAT); "Príncipe de Asturias" Universitary Hospital, Madrid, Spain (GB, MAT); Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain (DPP); Foundation for the Visual Quality (FUNCAVIS), Alicante, Spain (DPP); 1st University, Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece (AGPK, DGM); and University of Alcalá, Madrid, Spain (MAT).

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|August 14, 2013
PubMed
Summary

Primary open-angle glaucoma (POAG) is associated with significant changes in corneal shape. Glaucoma patients exhibit increased forward shifting of the posterior corneal surface compared to healthy individuals.

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Area of Science:

  • Ophthalmology
  • Corneal topography
  • Glaucoma research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding corneal biomechanics in POAG is crucial for diagnosis and management.
  • Corneal topography offers insights into ocular surface morphology.

Purpose of the Study:

  • To compare anterior and posterior corneal curvatures between eyes with primary open-angle glaucoma (POAG) and healthy eyes.
  • To investigate topographical differences in the cornea associated with POAG.

Main Methods:

  • Prospective, cross-sectional, observer-masked study.
  • 138 subjects (69 POAG eyes, 69 healthy control eyes) matched for age and central corneal pachymetry.
  • Orbscan II topography used to analyze anterior and posterior corneal elevation maps.

Main Results:

  • Eyes with POAG showed a significantly greater forward shift of the posterior corneal surface compared to healthy controls (p < 0.01).
  • Significant differences in anterior corneal elevation were also observed between POAG and control eyes (p < 0.01).

Conclusions:

  • POAG eyes exhibit a more elevated posterior corneal surface compared to matched healthy eyes.
  • These corneal topographical changes may play a role in the pathophysiology or diagnosis of POAG.