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Molecular characterization of Streptococcus pneumoniae serotype 1 invasive isolates in Colombia

Carolina Duarte1, Olga Sanabria, Jaime Moreno

  • 1Instituto Nacional de Salud, Bogotá, Colombia. jmoreno@ins.gov.co

Revista Panamericana De Salud Publica = Pan American Journal of Public Health
|August 14, 2013
PubMed
Abstract

Insights

Invasive Streptococcus pneumoniae serotype 1 disease in Colombia is mainly linked to the Sweden¹ ST306 clone. This contrasts with other countries where different clones are prevalent.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Streptococcus pneumoniae serotype 1 causes invasive disease globally.
  • Understanding the genetic lineage of invasive S. pneumoniae serotype 1 isolates is crucial for public health.
  • International clones represent dominant genetic lineages of S. pneumoniae.

Purpose of the Study:

  • To determine the genetic relationship between Colombian Streptococcus pneumoniae serotype 1 isolates and international clones.
  • To investigate the clonal origins of invasive S. pneumoniae serotype 1 in Colombia.

Main Methods:

  • Pulsed-field gel electrophoresis (PFGE) was used to analyze 135 S. pneumoniae serotype 1 isolates.
  • Multilocus sequence typing (MLST) was performed on selected isolates to confirm sequence types (STs).
  • Isolates were compared to reference strains and international clones like Sweden¹ ST306 and Sweden¹ ST304.

Main Results:

  • 89.7% of Colombian isolates were associated with the Sweden¹ ST306 clone.
  • 3.7% of isolates were associated with the Sweden¹ ST304 clone.
  • MLST confirmed ST306 in six isolates and ST304 in one.

Conclusions:

  • Invasive Streptococcus pneumoniae serotype 1 disease in Colombia is primarily driven by the Sweden¹ ST306 clone.
  • This finding differs from Brazil and the United States, where Sweden¹ ST304 and ST227 clones are more prevalent.
  • The study highlights the clonal diversity of S. pneumoniae serotype 1 globally.

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