Related Experiment Video
Updated: May 8, 2026
11:09
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting
Tom H Wright1, Anna E S Brooks, Alicia J Didsbury
1School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland Central, 1142 (New Zealand).
Angewandte Chemie (International Ed. in English)
|August 14, 2013
Abstract:
A radical lipidation: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates. The resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner.
