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Updated: May 8, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Beta sheets with a twist: the conformation of helical polyisocyanopeptides determined by using vibrational circular
Erik Schwartz1, Vincent Liégeois, Matthieu Koepf
1Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, 6525ED Nijmegen (The Netherlands).
Abstract:
Detailed information on the architecture of polyisocyanopeptides based on vibrational circular dichroism (VCD) spectroscopy in combination with DFT calculations is presented. It is demonstrated that the screw sense of the helical polyisocyanides can be determined directly from the C=N-stretch vibrational region of the VCD spectrum. Analysis of the VCD signals associated with the amide I and amide II modes provides detailed information on the peptide side-chain arrangement in the polymer and indicates the presence of a helical β-sheet architecture, in which the dihedral angles are slightly different to those of natural β-sheet helices.
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