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Related Concept Videos

The Tongue and Taste Buds00:49

The Tongue and Taste Buds

The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
Tangent to a Curve01:30

Tangent to a Curve

The graph of a function where each output is the square of the input creates a smooth curve that bends upward, becoming steeper as one moves further from the center. At any chosen position along this curve, the curve reaches a certain height depending on the input value. This position can be a reference for analyzing how the curve behaves in its immediate vicinity.To understand the change in the curve near a particular position, imagine selecting another point slightly ahead along the curve.
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The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...
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Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...
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Related Experiment Video

Updated: May 8, 2026

High-throughput, Automated Extraction of DNA and RNA from Clinical Samples using TruTip Technology on Common Liquid Handling Robots
10:47

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Published on: June 11, 2013

What is the point of tips?

L Adamczyk1, A Simpkin, J Oxley

  • 1Department of Cellular Pathology, Southmead Hospital, , Bristol, UK.

Journal of Clinical Pathology
|August 14, 2013
PubMed
Summary

The tip margin involvement in basal cell carcinoma (BCC) excisions is uncommon (5%). Macroscopic appearance and lateral margin involvement are key predictors, suggesting targeted embedding strategies for BCC treatment.

Area of Science:

  • Dermatology
  • Surgical Pathology

Background:

  • Basal cell carcinoma (BCC) is the most common skin cancer.
  • Accurate surgical excision margins are crucial for complete tumor removal and preventing recurrence.
  • Tip margin involvement in BCC excisions requires careful consideration for optimal surgical planning.

Purpose of the Study:

  • To determine the incidence of tip margin involvement in skin excisions for basal cell carcinoma (BCC).
  • To identify predictive factors for tip margin involvement in BCC excisions.
  • To inform surgical decision-making regarding the necessity of embedding BCC tips.

Main Methods:

  • Retrospective review of 793 BCC excisions from 642 patients.
  • Analysis of tip and peripheral lateral margin involvement.
Keywords:
HISTOPATHOLOGYSKINSKIN TUMOURS

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  • Statistical assessment of macroscopic and microscopic factors associated with tip margin involvement, using the Royal College of Pathologists (RCPath) dataset.

    • Main Results:

    • Tip margin involvement was observed in 5% of BCC specimens.
    • Peripheral lateral margin involvement occurred in 4% of cases.
    • Risk factors for tip margin involvement included macroscopically indiscernible lesions and peripheral lateral margin involvement.

    Conclusions:

    • The incidence of tip margin involvement in BCC excisions is low.
    • Embedding BCC tips may be unnecessary unless the lesion is macroscopically indiscernible or the peripheral lateral margin is involved.
    • These findings support a more targeted approach to margin assessment in BCC surgery.