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Updated: May 8, 2026
10:47
High-throughput, Automated Extraction of DNA and RNA from Clinical Samples using TruTip Technology on Common Liquid Handling Robots
Published on: June 11, 2013
What is the point of tips?
L Adamczyk1, A Simpkin, J Oxley
1Department of Cellular Pathology, Southmead Hospital, , Bristol, UK.
Journal of Clinical Pathology
|August 14, 2013
Summary
The tip margin involvement in basal cell carcinoma (BCC) excisions is uncommon (5%). Macroscopic appearance and lateral margin involvement are key predictors, suggesting targeted embedding strategies for BCC treatment.
Area of Science:
- Dermatology
- Surgical Pathology
Background:
- Basal cell carcinoma (BCC) is the most common skin cancer.
- Accurate surgical excision margins are crucial for complete tumor removal and preventing recurrence.
- Tip margin involvement in BCC excisions requires careful consideration for optimal surgical planning.
Purpose of the Study:
- To determine the incidence of tip margin involvement in skin excisions for basal cell carcinoma (BCC).
- To identify predictive factors for tip margin involvement in BCC excisions.
- To inform surgical decision-making regarding the necessity of embedding BCC tips.
Main Methods:
- Retrospective review of 793 BCC excisions from 642 patients.
- Analysis of tip and peripheral lateral margin involvement.
- Statistical assessment of macroscopic and microscopic factors associated with tip margin involvement, using the Royal College of Pathologists (RCPath) dataset.
Main Results:
- Tip margin involvement was observed in 5% of BCC specimens.
- Peripheral lateral margin involvement occurred in 4% of cases.
- Risk factors for tip margin involvement included macroscopically indiscernible lesions and peripheral lateral margin involvement.
Conclusions:
- The incidence of tip margin involvement in BCC excisions is low.
- Embedding BCC tips may be unnecessary unless the lesion is macroscopically indiscernible or the peripheral lateral margin is involved.
- These findings support a more targeted approach to margin assessment in BCC surgery.
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