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Related Experiment Videos

Radical surgery for lingual cancer.

J Pukander1, T Karhuketo, M Penttilä

  • 1Department of Otolaryngology, Tampere University Central Hospital, Finland.

Clinical Otolaryngology and Allied Sciences
|June 1, 1990
PubMed
Summary

Radical neck dissection significantly improves survival rates for tongue squamous cell carcinoma. Early-stage detection and surgical intervention are crucial for better patient outcomes in this cancer.

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How we do it: regular infusion of local anaesthetic in the pedicle of pectoralis major myocutaneous flap to shorten hospitalization of surgically treated head and neck cancer patients.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2005

Area of Science:

  • Oncology
  • Surgical Oncology
  • Head and Neck Cancer Research

Background:

  • Squamous cell carcinoma of the tongue is a significant cause of cancer-related mortality.
  • Treatment outcomes for tongue cancer have historically varied based on stage and therapeutic approach.
  • Understanding prognostic factors is essential for optimizing patient management.

Purpose of the Study:

  • To evaluate the survival rates of patients with squamous cell carcinoma of the tongue.
  • To compare the efficacy of different treatment modalities, specifically radical surgery versus other methods.
  • To identify prognostic indicators influencing survival in tongue cancer patients.

Main Methods:

  • Retrospective analysis of 58 patients treated for tongue squamous cell carcinoma between 1972 and 1985.

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  • Evaluation of overall and stage-specific 5-year survival rates.
  • Comparison of survival outcomes between composite pull-through resection with radical neck dissection and other treatments (local excision with radiation therapy).
  • Assessment of the impact of regional neck metastases (N stage) on survival.

    • Main Results:

    • The overall 5-year survival rate was 41.6%. Stage IV cancer had a 0% survival rate beyond 2 years.
    • Composite pull-through resection with radical neck dissection yielded a 50.7% 5-year survival rate, significantly higher than other treatments (13.8%, P < 0.01).
    • The presence of regional neck metastases significantly reduced 5-year survival (15.1% vs. 58.5% in N0 cases, P < 0.01).
    • Tumor location did not impact survival rates.

    Conclusions:

    • Radical neck dissection, as part of a composite pull-through resection, offers a significantly better survival prognosis for tongue squamous cell carcinoma compared to other treatments.
    • The presence and extent of neck metastases are critical negative prognostic factors.
    • Aggressive surgical management, particularly in earlier stages, is associated with improved survival outcomes.