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Related Concept Videos

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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Badger--an accessible genome exploration environment.

Ben Elsworth1, Martin Jones, Mark Blaxter

  • 1Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

Bioinformatics (Oxford, England)
|August 14, 2013
PubMed
Summary
This summary is machine-generated.

Generating high-quality genomes is now accessible. Badger offers a user-friendly environment for exploring next-generation non-model organism genomes, simplifying data accessibility.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Genome sequencing and assembly costs have decreased significantly, making high-quality draft genome generation more feasible.
  • Developing user-friendly, searchable web interfaces and databases for newly annotated genomes remains a challenge.

Purpose of the Study:

  • To present Badger, a novel genome exploration environment.
  • To provide an accessible solution for non-model organism genome data management and exploration.

Main Methods:

  • Badger is designed as a lightweight and easy-to-install system.
  • The environment facilitates the creation of searchable websites and databases for genomic data.

Main Results:

  • Badger simplifies the process of making newly annotated genomes accessible.
  • Demonstrated utility with a test dataset and four filarial nematode genomes.

Conclusions:

  • Badger addresses the challenge of creating user-friendly interfaces for next-generation genomes.
  • This tool enhances the accessibility and exploration of genomic data, particularly for non-model organisms.