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Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers

Solid Phase ¹¹C-Methylation, Purification and Formulation for the Production of PET Tracers

Published on: October 24, 2019

Longitudinal amyloid imaging using 11C-PiB: methodologic considerations.

Bart N M van Berckel¹, Rik Ossenkoppele, Nelleke Tolboom

¹Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. b.berckel@vumc.nl

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|August 14, 2013

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Quantitative analysis is essential for reliable measurement of amyloid binding over time. Fully quantitative methods are crucial for longitudinal changes in (11)C-PiB binding, especially in drug trials.

Area of Science:

Neuroimaging
Radiochemistry
Biomarker Analysis

Background:

Several analytical methods exist for (11)C-Pittsburgh compound-B ((11)C-PiB) data.
Accurate measurement of longitudinal changes in (11)C-PiB binding is critical for research and clinical applications.

Purpose of the Study:

To identify the optimal method for quantifying longitudinal changes in specific (11)C-PiB binding.
To compare the performance of different analytical techniques in measuring changes in amyloid binding over time.

Main Methods:

Dynamic 90-min (11)C-PiB scans were acquired from Alzheimer's disease (AD) patients, mild cognitive impairment (MCI) patients, and healthy controls.
Parametric images were generated using reference parametric mapping (RPM2), reference Logan values, and standardized uptake value ratios (SUVr).

Keywords:

11C-Pittsburgh compound-B Alzheimer disease SUVr positron emission tomography receptor parametric mapping reference Logan

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Percentage change between baseline and follow-up was calculated for each analytic method, using cerebellar gray matter as a reference region.

Main Results:

SUVr methods overestimated binding compared to RPM2 and showed high intersubject variability.
Reference Logan values were slightly lower than RPM2.
Simulations indicated SUVr's high dependence on uptake period and sensitivity to flow changes, unlike RPM2 and reference Logan values.

Conclusions:

Fully quantitative methods are essential for reliable assessment of amyloid binding over time.
This is particularly important for longitudinal studies, such as drug intervention trials.
The choice of analytical method significantly impacts the accuracy of measuring changes in (11)C-PiB binding.