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Related Experiment Video

Updated: May 8, 2026

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017

Mouse strain determines cardiac growth potential.

Carmen Kiper1, Barry Grimes, Gary Van Zant

  • 1Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Plos One
|August 14, 2013
PubMed
Summary
This summary is machine-generated.

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DBA/2 mice exhibit a more immature cardiac phenotype, showing greater heart growth and a protective response to hypertrophy compared to C57BL/6 mice. This highlights genetic influences on cardiac pathology and mouse model selection.

Area of Science:

  • Cardiovascular Research
  • Genetics and Physiology
  • Animal Models in Cardiology

Background:

  • Genetic background significantly influences heart disease development and progression.
  • Selecting appropriate mouse models is crucial for studying cardiac pathology.
  • This study investigates cardiac growth differences between C57BL/6 and DBA/2 mouse strains.

Purpose of the Study:

  • To test the hypothesis that C57BL/6 and DBA/2 mouse strains exhibit varying degrees of heart growth.
  • To compare cardiac responses in physiological and pathological settings between the two strains.
  • To elucidate strain-specific differences in cardiac development and response to stimuli.

Main Methods:

  • Echocardiography to assess heart dimensions at 8 weeks.

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Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
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Published on: June 21, 2016

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

Related Experiment Videos

Last Updated: May 8, 2026

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

  • Analysis of cardiac progenitor cells (c-kit+), nucleated cell types, and cardiomyocyte turnover.
  • Assessment of cardiomyocyte size and nucleated cell percentages with age.
  • Isoproterenol stimulation to induce hypertrophy and measurement of cardiac growth and ANF expression.

    • Main Results:

    • Detectable differences in heart dimensions by echocardiography at 8 weeks.
    • DBA/2 mice showed higher percentages of cardiac progenitor cells and mononucleated cells; C57BL/6 mice had more tri- and quad-nucleated cells.
    • DBA/2 mice exhibited greater cardiomyocyte cell size increase with age and enhanced cardiac growth (cardiomyocyte and whole heart) following isoproterenol stimulation, with higher ANF expression.
    • Higher apoptotic activity was observed in DBA/2 mice, with no significant change in mitotic activity.

    Conclusions:

    • DBA/2 mice possess a more immature cardiac phenotype.
    • This immature phenotype correlates with a cardiac protective response to hypertrophy under both physiological and pathological conditions.
    • Strain-specific cardiac phenotypes are critical for understanding heart disease and for selecting appropriate animal models.