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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Opioid Analgesics: Morphine and Other Natural Cogeners

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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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Long-term opioid therapy for chronic pain: optimizing management, minimizing risk.

Jennifer L Roux1

  • 1Carolinas Pain Institute, 145 Kimel Park Dr, Ste 330, Winston-Salem, NC 27106, USA. jroux@ccrpain.com

North Carolina Medical Journal
|August 15, 2013
PubMed
Summary
This summary is machine-generated.

Opioid analgesics effectively manage chronic noncancer pain for some patients. However, these potent pain relievers are a major factor in the current national epidemic of opioid misuse and illegal diversion.

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Area of Science:

  • Pain Management
  • Pharmacology
  • Public Health

Background:

  • Opioid analgesics are frequently prescribed for chronic noncancer pain.
  • While effective for certain individuals, their use is linked to significant public health concerns.

Purpose of the Study:

  • To examine the role of opioid analgesics in chronic noncancer pain management.
  • To address the ongoing national epidemic of opioid misuse and diversion.

Main Methods:

  • Literature review of opioid efficacy in chronic noncancer pain.
  • Analysis of data on opioid misuse and diversion rates.
  • Epidemiological study of the opioid crisis.

Main Results:

  • Opioid analgesics demonstrate variable efficacy in chronic noncancer pain.
  • Significant rates of misuse and diversion are associated with opioid analgesic prescriptions.
  • The national opioid crisis is largely driven by the misuse of these pain medications.

Conclusions:

  • Opioid analgesics present a dual challenge in pain management and public health.
  • Careful patient selection and monitoring are crucial to mitigate risks.
  • Addressing the opioid epidemic requires multifaceted strategies beyond clinical use.