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Alterations in placental pendrin expression in pre-eclampsia
Ahmet Karatas1, Havva Erdem, Mustafa Albayrak
1Department of Obstetrics and Gynecology, School of Medicine, Abant Izzet Baysal University , Bolu , Turkey .
Introduction:
Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue.
Methods:
Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense.
Results:
There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r=0.533, p=0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group.
Conclusions:
Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.
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