C-H functionalization of cyclopropanes: a practical approach employing a picolinamide auxiliary
Daniela Sustac Roman1, André B Charette
1Centre in Green Chemistry and Catalysis, Department of Chemistry, Université de Montréal, P.O. Box 6128 Station Downtown, Montréal, Québec H3C 3J7, Canada.
Abstract:
A Pd-catalyzed, picolinamide-enabled, and efficient C-H arylation of cyclopropanes is described. The reaction can be promoted by either a silver additive or catalytic pivalic acid in the presence of a carbonate base. Various aryl iodides can be employed as coupling partners, providing exclusively cis-substituted cyclopropylpicolinamides.
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