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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular
Vincent Ladmiral1, Mona Semsarilar, Irene Canton
1Department of Chemistry, University of Sheffield , Brook Hill, Sheffield, South Yorkshire, S3 7HF, United Kingdom.
Abstract:
Recent advances in polymer science are enabling substantial progress in nanobiotechnology, particularly in the design of new tools for enhanced understanding of cell biology and for smart drug delivery formulations. Herein, a range of novel galactosylated diblock copolymer nano-objects is prepared directly in concentrated aqueous solution via reversible addition-fragmentation chain transfer polymerization using polymerization-induced self-assembly. The resulting nanospheres, worm-like micelles, or vesicles interact in vitro with galectins as judged by a turbidity assay. In addition, galactosylated vesicles are highly biocompatible and allow intracellular delivery of an encapsulated molecular cargo.
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