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Updated: May 8, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
A derivative of ascorbic acid modulates cAMP production
B Bordignon1, S Mones, F Rahman
1N.O.R.T.: Nutrition, Obesity and Risk of Thrombosis, Aix-Marseille University, INSERM U 1062, INRA 1260, 27 boulevard Jean Moulin, F-13385 Marseille, France.
Abstract:
We reported, in previous experiments, that AA is a global regulator of cAMP pools. In this study, we demonstrate that K873, an analog of AA we synthesized and presenting antiproliferative properties, has also an impact on cAMP production. However, K873 has no antioxidant activity, at the contrary of AA. It definitively demonstrates that action of AA on the cAMP production is not linked to antioxidant activity. These data suggest that AA, and derivatives of this molecule, could be promising drug acting on biological processes that are under the control of cAMP dependent pathway.
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