Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 8, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Myxoid lipoblastoma.

Janani Krishnan1, Varun Hathiramani, Meenal Hastak

  • 1Department of Pediatric Surgery, Lilavati Hospital and Research Centre, Mumbai, India. jankrish.doc@gmail.com

Indian Pediatrics
|August 15, 2013
PubMed
Summary

Differentiating infant axillary masses like lipoblastoma from liposarcoma is crucial. Histopathology, immunohistochemistry, and PLAG1 gene analysis confirm diagnosis, guiding treatment and avoiding unnecessary surgery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ingestion and aspiration of hot candle wax.

BMJ case reports·2025
Same author

Perioperative, oncological, and survival outcomes of robotic radical cystectomy with urinary diversion in females: A single-center retrospective observational study.

Indian journal of urology : IJU : journal of the Urological Society of India·2023
Same author

Mutational Analysis of EGFR Mutations in Non-Small Cell Lung Carcinoma-An Indian Perspective of 212 Patients.

International journal of environmental research and public health·2023
Same author

A Difficult Case of Pyrexia of Unknown Origin.

Indian journal of pediatrics·2021
Same author

Neurolymphomatosis as a Presenting Feature of Primary Testicular Lymphoma.

Annals of Indian Academy of Neurology·2021
Same author

Role of ano rectal myomectomy in children with chronic refractory constipation.

African journal of paediatric surgery : AJPS·2019

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology
  • Molecular Diagnostics

Background:

  • Infantile soft tissue masses in the axilla can present diagnostic challenges, with lipoblastoma and liposarcoma being key differential diagnoses.
  • Accurate diagnosis is essential to prevent overtreatment and guide appropriate management strategies for pediatric patients.

Observation:

  • A case of a rapidly growing infant axillary soft tissue mass is presented, necessitating precise diagnostic evaluation.
  • The clinical presentation raised suspicion for either a benign lipoblastoma or a malignant liposarcoma.

Findings:

  • Histopathology and immunohistochemistry serve as the gold standard for distinguishing lipoblastoma from liposarcoma.
  • In ambiguous cases, detecting genetic rearrangement of the pleomorphic adenoma gene 1 (PLAG1) oncogene aids in confirming lipoblastoma.

Implications:

  • This highlights the importance of advanced diagnostic techniques in pediatric soft tissue tumors.
  • Accurate differentiation prevents aggressive surgical intervention for benign conditions like lipoblastoma.

Related Experiment Videos

Last Updated: May 8, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024