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Related Experiment Video

Updated: May 8, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror.

Donglin Wang¹, Linlai Fu, Xin Wang

¹University of Shanghai for Science and Technology, Ministry of Education, Shanghai Key Lab of Modern Optical System, Engineering Research Center of Optical Instrument and System, No. 516 JunGong Road, Shanghai 200093, China.

Journal of Biomedical Optics

|August 15, 2013

Summary

A novel endoscopic swept-source optical coherence tomography (SS-OCT) system utilizes a microelectromechanical system (MEMS) mirror for high-speed 3-D imaging. This technology successfully visualized oral tissues in vivo, correlating well with histopathology.

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Area of Science:

Biomedical Engineering
Optical Imaging
Microtechnology

Background:

Optical Coherence Tomography (OCT) is a valuable non-invasive imaging technique.
Endoscopic OCT allows for in vivo visualization of internal tissues.
Miniaturization of OCT systems is crucial for advanced endoscopic applications.

Purpose of the Study:

To develop and demonstrate a high-speed, 3-D microelectromechanical system (MEMS) mirror-based endoscopic swept-source OCT (SS-OCT) system.
To evaluate the system's capability for in vivo imaging of oral tissues.
To compare OCT imaging results with histopathological analysis.

Main Methods:

A compact two-axis MEMS scanning mirror (0.8x0.8 mm2 mirror plate, 1.6x1.4 mm2 footprint) was integrated into an SS-OCT system.
The endoscopic probe had a small diameter of 3.5 mm.
The system achieved an imaging rate of 50 frames/s for 3-D volumetric data acquisition.

Main Results:

The MEMS-based endoscopic SS-OCT system successfully acquired 3-D images of human oral tissues.
In vivo imaging of suspicious oral leukoplakia and normal buccal mucosa was performed.
The OCT imaging findings demonstrated strong agreement with subsequent histopathological analysis.

Conclusions:

The developed MEMS mirror-based endoscopic SS-OCT system enables high-speed, 3-D in vivo imaging with a miniaturized probe.
This technology shows significant potential for the diagnosis and characterization of oral lesions.
The system's performance validates its utility in clinical endoscopic applications.