Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relation between connective tissue cells and intercellular substances, including basement membranes.

P Davies, A C Allison, C J Cardella

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |July 17, 1975
    PubMed
    Summary

    Basement membranes, crucial extracellular matrices for cells, can be damaged by inflammation or physical separation. Understanding these cellular interactions is key to studying diseases affecting basement membranes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Observational, hypothesis-driven and genomics research strategies for analyzing inherited differences in responses to infectious diseases.

    Public health genomics·2012
    Same author

    Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation.

    Journal of thrombosis and haemostasis : JTH·2012
    Same author

    Disc angiogenesis assay.

    Methods in molecular medicine·2011
    Same author

    Diannexin, a novel annexin V homodimer, protects rat liver transplants against cold ischemia-reperfusion injury.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
    Same author

    Mechanisms of action of mycophenolate mofetil.

    Lupus·2005
    Same author

    Mechanisms of action of mycophenolate mofetil in preventing chronic rejection.

    Transplantation proceedings·2002

    Area of Science:

    • Cell Biology
    • Pathology
    • Extracellular Matrix Research

    Background:

    • Basement membranes are vital extracellular matrices synthesized by epithelial and endothelial cells.
    • These membranes play a critical role in cell adhesion, differentiation, and tissue structure.
    • Disruptions in basement membrane integrity are implicated in various pathological conditions.

    Purpose of the Study:

    • To explore the pathological changes in basement membranes and their associated cells.
    • To elucidate the mechanisms underlying basement membrane damage in disease.
    • To investigate cellular interactions within the pericellular environment.

    Main Methods:

    • Review of pathological changes in basement membranes.
    • Analysis of basement membrane degradation by hydrolytic enzymes.

    Related Experiment Videos

  • Examination of physical separation effects on cell-matrix interactions.

    • Main Results:

    • Basement membrane damage occurs via enzymatic degradation and physical displacement of cells.
    • Immune complex deposition in glomerulonephritis exemplifies physical separation.
    • Asbestos inhalation in lung disease illustrates inflammatory degradation.
    • Cellular separation interferes with basement membrane synthesis and cell proliferation.

    Conclusions:

    • Cellular interactions with basement membranes are fundamental to tissue homeostasis.
    • Pathological changes involve both direct degradation and indirect interference with cellular signaling.
    • Further cellular-level studies can illuminate disease mechanisms and potential therapeutic targets.