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Updated: May 8, 2026

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Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
Published on: September 1, 2018
Eyeblink conditioning: a non-invasive biomarker for neurodevelopmental disorders
Bethany C Reeb-Sutherland1, Nathan A Fox
1Department of Psychology, DM 256, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA, besuther@fiu.edu.
Journal of Autism and Developmental Disorders
|August 15, 2013
Summary
Eyeblink conditioning (EBC) is a valuable tool for understanding learning and memory. This review highlights EBC
Area of Science:
- Neuroscience
- Developmental Psychology
- Behavioral Science
Background:
- Eyeblink conditioning (EBC) is a classical conditioning paradigm.
- It has a well-defined neural circuitry and is non-invasive.
- EBC is suitable for studying learning and memory in various populations, including infants.
Purpose of the Study:
- To review studies using EBC as a biomarker for neurodevelopmental disorders.
- To discuss the utility of EBC in individuals with autism spectrum disorders (ASDs).
Main Methods:
- Literature review of studies employing EBC.
- Analysis of EBC's role in neurodevelopmental disorders.
Main Results:
- EBC has been used as a biomarker for fetal alcohol syndrome, Down syndrome, fragile X syndrome, ADHD, dyslexia, specific language impairment, and schizophrenia.
- Abnormalities in the cerebellum, crucial for EBC, are linked to neurodevelopmental disorders.
Conclusions:
- EBC is a promising biomarker for neurodevelopmental disorders.
- Its application in individuals with ASD warrants further investigation.

