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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Transgenic Organisms00:53

Transgenic Organisms

Overview

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Related Experiment Video

Updated: May 8, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Transgenic mouse models.

Jennifer Skelton1, Linda H Gower, Anne McGough

  • 1Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 15, 2013
PubMed
Summary

This guide provides detailed specifics for generating transgenic mouse models, a widely used technique in biological research. It serves as a practical "how-to" resource for researchers utilizing this powerful technology.

Area of Science:

  • Genetics and Genomics
  • Animal Models

Background:

  • Transgenic mouse models are essential tools in biological research, established for decades.
  • Existing literature includes general reviews but lacks detailed procedural guidance.

Purpose of the Study:

  • To provide a comprehensive "how-to" manual for generating transgenic mouse models.
  • To offer detailed specifics beyond general reviews of the technology.

Main Methods:

  • Detailed step-by-step protocols for transgenic mouse generation.
  • Specifics on common techniques and potential challenges.

Main Results:

  • A practical resource enabling researchers to efficiently generate transgenic mice.
  • Facilitation of reproducible research through clear methodological instructions.

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Related Experiment Videos

Last Updated: May 8, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

Expanding the Toolkit for In Vivo Imaging of Axonal Transport
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Expanding the Toolkit for In Vivo Imaging of Axonal Transport

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Conclusions:

  • This chapter serves as an indispensable practical guide for researchers creating transgenic mouse models.
  • It aims to enhance the successful application of transgenic technology in diverse research areas.