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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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Published on: June 24, 2020

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges.

Andrew P Hutchins1, Diego Diez, Diego Miranda-Saavedra

  • 1Bioinformatics and Genomics Laboratory, World Premier International (WPI) Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, 565-0871 Osaka, Japan. Tel.: +81 6 6879 4269; Fax: +81 6 6879 4272; diego@ifrec.osaka-u.ac.jp.

Briefings in Functional Genomics
|August 15, 2013
PubMed
Summary

Interleukin 10 (IL-10) resolves inflammation by controlling immune responses. This review details how STAT3 transcription factor and its co-factors regulate the IL-10 anti-inflammatory response (AIR) in macrophages.

Keywords:
IL-10JAK1STAT3anti-inflammatory responsebioinformaticsmacrophagestranscriptional regulatory modules

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genomics

Background:

  • Inflammation is a critical immune response for pathogen elimination and tissue repair.
  • The interleukin 10 (IL-10)-mediated anti-inflammatory response (AIR) is vital for controlling inflammation's extent and duration.
  • Understanding AIR mechanisms is key to managing inflammatory diseases.

Purpose of the Study:

  • To review recent mechanistic studies of the IL-10-mediated AIR.
  • To explore the in vivo genomic targets of STAT3, a key downstream transcription factor of IL-10.
  • To identify co-factors that confer STAT3 genomic-binding specificity.

Main Methods:

  • Genomic and computational approaches are employed.
  • Cataloguing in vivo genomic targets of STAT3.
  • Identifying specific co-factors for STAT3.

Main Results:

  • Recent work has characterized IL-10-mediated AIR mechanisms at multiple levels.
  • In vivo genomic targets of STAT3 have been catalogued.
  • Specific co-factors that provide STAT3 with genomic-binding specificity have been identified.

Conclusions:

  • The study elucidates the regulatory mechanisms of the IL-10-mediated AIR in macrophages.
  • Genomic and computational methods are powerful tools for understanding this essential physiological response.
  • Further research into these mechanisms could inform therapeutic strategies for inflammatory conditions.