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Simultaneous T(1) and B(1) (+) mapping using reference region variable flip angle imaging.

Kyunghyun Sung1, Manojkumar Saranathan, Bruce L Daniel

  • 1Department of Radiological Sciences, UCLA, Los Angeles, California, USA.

Magnetic Resonance in Medicine
|August 15, 2013
PubMed
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This study introduces a new Reference Region Variable Flip Angle (RR-VFA) method for simultaneous T1 and B1 (+) mapping in MRI. This technique improves T1 quantification accuracy without increasing scan time.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Quantitative Imaging
  • Biomedical Engineering

Background:

  • Accurate T1 and B1 (+) mapping are crucial for quantitative MRI.
  • Conventional methods for T1 and B1 (+) mapping can be time-consuming or less accurate.
  • Fat is a suitable reference region for B1 (+) field inhomogeneity due to its well-characterized T1 relaxation time.

Purpose of the Study:

  • To present a novel Reference Region Variable Flip Angle (RR-VFA) imaging method.
  • To enable simultaneous and efficient measurement of T1 and B1 (+) maps.
  • To improve T1 quantification in Magnetic Resonance Imaging (MRI).

Main Methods:

  • Utilized fat-only images from two-point Dixon acquisitions to compute B1 (+) maps.
  • Compared RR-VFA derived B1 (+) maps with the double-angle method (DAM) in 22 breast MRI patients at 3T.
Keywords:
B1 field inhomogeneityT1 mappingbreast imaginghigh‐field MRIquantitative DCE‐MRI

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  • Acquired high spatial resolution Variable Flip Angle (VFA) images for T1 measurements with and without RR-VFA B1 (+) correction.

    • Main Results:

    • RR-VFA generated reliable B1 (+) maps comparable to the conventional DAM.
    • Simultaneous T1 and B1 (+) mapping reduced T1 estimation errors.
    • Improved T1 maps showed more uniform fibroglandular tissue T1 and better depiction of heterogeneous breast masses.

    Conclusions:

    • A new method for simultaneous T1 and B1 (+) mapping using Dixon VFA images was developed.
    • The RR-VFA method offers improved T1 quantification.
    • This technique achieves enhanced accuracy without any penalty to scan time.