Related Experiment Video
Updated: Aug 16, 2026

Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling
Published on: August 1, 2016
Heart muscle: mathematical modelling of the mechanical activity and modelling of mechanochemical uncoupling
L B Katsnelson1, Izakov VYa, V S Markhasin
1Laboratory of Biophysics, Institute of Industrial Hygiene and Occupational Diseases, Sverdlovsk, USSR.
Abstract:
A mechanical model of heart muscle is proposed which includes rheological equations and equations for Ca-troponin interaction, for the dependences of the number of myosin cross-bridges on the length of sarcomere and on the speed of motion. The main assumption of the model is the dependence of the troponin affinity to calcium ions on the number of myosin cross-bridges attached. The model successfully imitates isometric and isotonic contractions, the "length-force" relationships, load-dependent relaxation, and the group of mechanical phenomena known as mechanochemical uncoupling.
More Related Videos
Related Concept Videos
Cross-bridge Cycle
Excitation-Contraction Coupling in Skeletal Muscles
When an action potential...
Motor Unit Stimulation
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Structure of Cardiac Muscles
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Specialized Characteristics of Cardiac Muscles
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Pathophysiology of Cardiac Performance

