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Updated: May 8, 2026
Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
[Analysis of alkaloids in Zanthoxylum nitidum by HPLC-DAD/ESI-Q-TOF-MS]
Chang-Ping Jia1, Xue-Li Huang, Yun Li
1Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. jcp841006@yahoo.com.cn
Abstract:
The alkaloids in Zanthoxylum nitidum were identified by HPLC-DAD/ESI-Q-TOF-MS. Separation was performed on a Hanbon C18 column with acetonitrile (with 0.1% formic acid) and water(with 0.1% formic acid) as mobile phase. Based on the high-resolution mass information, MS/MS fragmentation behaviors and chemical components from literatures, 48 components were identified or tentatively characterized including 6 new compounds. This work could be useful for the quality control and further studies of the plant.
