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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
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Mandatory single embryo transfer policy dramatically decreases multiple pregnancy rates.

Ibrahim Esinler1, Gurkan Bozdag, Lale Karakoc Sokmensuer

  • 1Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The Journal of Obstetrics and Gynaecology Research
|August 16, 2013
PubMed
Summary

A mandatory single embryo transfer (SET) policy significantly reduced multiple pregnancies in intracytoplasmic sperm injection (ICSI) cycles. While SET decreased pregnancy rates with day-3 transfers, day-5 transfers maintained success rates.

Keywords:
assisted reproductive technologyintracytoplasmic sperm injectionmandatory single embryo transfermultiple pregnanciessingle embryo transfer

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Public Health Policy

Background:

  • Intracytoplasmic sperm injection (ICSI) is a key assisted reproductive technology.
  • Multiple pregnancies pose significant risks to both mother and child.
  • Regulatory policies impact IVF outcomes and patient safety.

Purpose of the Study:

  • To evaluate the impact of a mandatory single embryo transfer (SET) policy on pregnancy and multiple pregnancy rates.
  • To compare outcomes of ICSI cycles before and after the implementation of SET legislation.
  • To assess the influence of embryo developmental stage (day-3 vs. day-5 transfer) on SET policy effectiveness.

Main Methods:

  • Retrospective analysis of ICSI cycles before and after mandatory SET legislation.
  • Categorization of cycles into pre-legislation (multiple transfers), post-legislation day-3 SET, and post-legislation day-5 SET.
  • Comparison of clinical pregnancy, live birth, implantation, miscarriage, and multiple pregnancy rates across groups.

Main Results:

  • The mandatory SET policy drastically reduced multiple pregnancy rates (39.6% vs. 0.0%).
  • Clinical pregnancy and live birth rates were significantly lower in the day-3 SET group compared to the pre-legislation group.
  • Day-5 SET maintained comparable pregnancy and live birth rates to the pre-legislation group, with no multiple pregnancies.
  • Implantation rates were highest in the day-5 SET group.

Conclusions:

  • Mandatory SET effectively minimizes multiple pregnancies in ICSI.
  • Day-3 embryo transfers under SET policy can reduce pregnancy success.
  • Day-5 embryo transfers under SET policy preserve pregnancy and live birth rates, offering a viable alternative to multiple embryo transfers.