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Published on: September 13, 2022

A randomised controlled trial of plasma filtration in severe paediatric sepsis

Elliot J Long1, Anna Taylor, Carmel Delzoppo

  • 1Royal Children's Hospital, Melbourne, VIC, Australia. elliot.long@rch.org.au

Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine
|August 16, 2013
PubMed

Insights

Plasma filtration did not significantly improve 28-day survival in children with severe sepsis. This study was underpowered due to poor recruitment, but found no significant difference in mortality between groups.

Area of Science:

  • Pediatric critical care medicine
  • Sepsis research
  • Extracorporeal therapies

Background:

  • Severe sepsis in children is a life-threatening condition.
  • Standard therapy for septic shock has limitations.
  • Plasma filtration is a potential adjunctive treatment.

Purpose of the Study:

  • To evaluate if plasma filtration improves 28-day survival in pediatric severe sepsis.
  • To assess the impact of plasma filtration on organ system failure and mortality.

Main Methods:

  • A multicenter randomized controlled trial involving 48 infants and children with severe sepsis.
  • Patients were assigned to plasma filtration or standard therapy.
  • Primary outcome was 28-day survival; secondary outcomes included organ failure and functional status.

Main Results:

  • The trial was halted early due to insufficient recruitment.
  • Plasma filtration group had higher initial disease severity.
  • No significant difference in 28-day mortality was observed between groups after adjusting for illness severity.

Conclusions:

  • The study was underpowered to determine the efficacy of plasma filtration for severe sepsis in children.
  • Plasma filtration did not demonstrate a significant survival benefit in this trial.
  • Further research with adequate patient numbers is needed.
Abstract

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