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Mapping the human gene coding for chromosomal protein HMG-17.

N Popescu1, D Landsman, M Bustin

  • 1Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Human Genetics
|August 1, 1990
PubMed
Summary

The gene for nonhistone chromosomal protein HMG-17, important for active gene chromatin, is located at band 1p36.1. Multiple nonfunctional copies of this gene are found on other chromosomes.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Chromatin Structure

Background:

  • Nonhistone chromosomal protein HMG-17 is a nucleosomal binding protein.
  • HMG-17 may impart unique properties to the chromatin structure of active genes.

Purpose of the Study:

  • To map the functional gene coding for nonhistone chromosomal protein HMG-17.
  • To identify the chromosomal location of HMG-17 retropseudogenes.

Main Methods:

  • Gene mapping techniques were employed.
  • Chromosomal analysis was performed to locate gene copies.

Main Results:

  • The functional HMG-17 gene was mapped to chromosome band 1p36.1.
  • Numerous nonfunctional HMG-17 retropseudogenes were identified across multiple chromosomes.

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Conclusions:

  • The primary functional HMG-17 gene resides in a specific chromosomal location (1p36.1).
  • The presence of multiple retropseudogenes suggests a complex evolutionary history or gene duplication events for HMG-17.