Related Experiment Video
Updated: May 8, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
Effect of intra-abdominal volume increment on lungs in hemorrhagic shock
Purpose:
Intra-abdominal hypertension (IAH) causes lung dysfunction in patients after hemorrhagic shock resuscitation. We performed intra-abdominal volume increment (IAVI) to IAH and studied its effect on pulmonary function.
Methods:
Eight minipigs established for IAH model by exsanquination until shock, incomplete blockage of portal vein and overload resuscitation were randomly divided into IAVI group (n=4) and sham-operated control group (n=4). Bladder pressure, arterial blood gas analysis and thoraco-abdominal computed tomography (CT) scans were measured. The minipigs were sacrificed 26 h after surgery, and lung samples were harvested for measuring the wet-to-dry weight ratio and hematoxylin-eosin staining.
Results:
Compared with sham-operated control group, the respiratory rate and paCO2 remarkably decreased and paO2 notably increased at 8 and 12 h in the IAVI group. The bladder pressure also notably decreased at 8, 12, and 22 h after IAVI treatment. However, a significant improvement in diaphragm height was observed at 22 h after IAVI treatment. The wet-to-dry weight ratio of the lungs in IAVI group was also significantly higher than that that in the sham-operated control group.
Conclusion:
Our data indicate that IAVI surgery could improve the damaged pulmonary function caused by IAH after hemorrhagic shock resuscitation (Tab. 1, Fig. 7, Ref. 21).
Related Concept Videos
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...
Pneumothorax II: Pathophysiology
Increased Intracranial Pressure l: Introduction
Breathing
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Intestinal Obstruction II: Pathophysiology

