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Updated: May 8, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Characterization of micellar systems produced by new amphiphilic conjugates of poly(ethylene glycol)
R Pignatello1, V Pantò, L Basile
1Sezione di Tecnologia Farmaceutica, Dipartimento di Scienze del Farmaco, Università degli Studi di Catania - Viale A. Doria , Catania , Italy .
Abstract:
This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG2000 and three different α-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10(-5 )M, that are interesting in the view of an in vivo administration. The PEG-LAA micelles also showed a good stability at 37 °C and upon dilution in aqueous media. Using a colored probe as a model lipophilic compound, the loading efficiency and in vitro release profile were also outlined.
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