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Inflammatory Bowel Disease II: Ulcerative Colitis

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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Published on: February 1, 2012

Serum m 30 levels reflects ulcerative colitis activity.

Bora Aktaş1, Akif Altınbaş, Omer Başar

  • 1*Department of Gastroenterology, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey; †Department of Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey; and ‡Department of Biochemistry, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.

Inflammatory Bowel Diseases
|August 16, 2013
PubMed
Summary

Serum M 30 levels are elevated in active ulcerative colitis, indicating increased epithelial cell apoptosis. This finding supports apoptosis's role in the pathogenesis of active ulcerative colitis, offering a potential biomarker for disease activity.

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Area of Science:

  • Gastroenterology
  • Cell Biology
  • Immunology

Background:

  • Ulcerative colitis pathogenesis involves epithelial and mucosal injury.
  • Increased epithelial cell apoptosis is observed in ulcerative colitis.
  • Serum M 30 levels correlate with epithelial cell apoptosis.

Purpose of the Study:

  • To investigate the relationship between serum M 30 levels and ulcerative colitis activity.
  • To assess M 30 as a potential biomarker for active disease.

Main Methods:

  • Eighty ulcerative colitis patients and 40 healthy controls were recruited.
  • Ulcerative colitis activity was assessed clinically and endoscopically.
  • Serum M 30 levels, acute phase reactants, and biochemical tests were analyzed.

Main Results:

  • Serum M 30 levels were significantly higher in active ulcerative colitis patients compared to controls.
  • Active left-sided colitis patients showed higher M 30 levels than those in remission.
  • Excluding proctitis, active ulcerative colitis patients had significantly higher M 30 levels than those in remission.

Conclusions:

  • Serum M 30 levels are elevated in active ulcerative colitis.
  • These findings support the role of apoptosis in active ulcerative colitis pathogenesis.
  • Serum M 30 may serve as a biomarker for ulcerative colitis activity.