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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
Natriuretic peptides and fat metabolism
1aInserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases (I2MC) bUMR1048, Paul Sabatier University, Toulouse, France.
Current Opinion in Clinical Nutrition and Metabolic Care
|August 16, 2013
Summary
Cardiac natriuretic peptides are potent metabolic hormones. Lower levels in obesity may lead to type 2 diabetes, suggesting therapeutic potential for metabolic diseases.
Area of Science:
- Endocrinology
- Metabolic Physiology
- Molecular Biology
Background:
- Cardiac natriuretic peptides (CNPs) function as critical metabolic hormones.
- Recent research underscores their significance in metabolic health and disease.
Purpose of the Study:
- To review recent findings on the role of CNPs in metabolic physiology.
- To highlight the connection between CNPs and metabolic diseases like obesity and type 2 diabetes.
Main Methods:
- Discussion of signaling pathways, including cyclic guanosine monophosphate (cGMP).
- Review of studies on fat browning, thermogenesis, and oxidative capacity in skeletal muscle.
- Analysis of population-based studies and the gut-heart axis in relation to CNPs.
Main Results:
- CNP signaling via cGMP promotes white fat browning and thermogenesis.
- CNPs enhance mitochondrial fat oxidation and respiration in skeletal muscle, mimicking exercise adaptations.
- Reduced circulating CNPs are observed in obesity and predict type 2 diabetes.
- A direct link between CNPs and type 2 diabetes via a gut-heart axis has been established.
Conclusions:
- CNPs play a vital role in maintaining metabolic homeostasis.
- Deficiency in CNPs during obesity can precipitate metabolic dysfunction and type 2 diabetes.
- Strategies to increase CNP levels and signaling may combat obesity-related metabolic complications.
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