Human rabies--South Carolina, 2011
Related Experiment Video
Updated: May 8, 2026

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
Published on: August 18, 2023
Abstract:
On December 3, 2011, a South Carolina woman visited a local emergency department (ED) with an overnight history of shortness of breath, diaphoresis, chills, and intermittent paresthesia. The patient was transferred to a referral hospital, where she became comatose and developed multiorgan failure. The patient did not report a history of an animal bite. However, family members subsequently revealed that bats had been observed in the patient's home during the previous summer. Family members also reported that the patient had sought information on bat removal from a local county service, but was not advised of the risk for rabies associated with bat exposures and was not referred for public health consultation. CDC confirmed infection with a rabies virus variant associated with Mexican free-tailed bats (Tadarida brasiliensis) on December 14, after which the patient received hospice care. She died on December 19. This report summarizes the patient's clinical course and the associated public health investigation. This case highlights the importance of strong partnerships among public health officials and diverse non-health-care partners to ensure appropriate referral of persons exposed to bats in their homes for prompt and appropriate risk assessment, postexposure prophylaxis (PEP) recommendations, and information on safe, effective, and humane bat exclusion methods.
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