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Updated: Jan 18, 2026
Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
Published on: January 28, 2021
Nanoelectronics meets biology: from new nanoscale devices for live-cell recording to 3D innervated tissues
Xiaojie Duan1, Charles M Lieber
1Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871 (P.R. China) http://en.coe.pku.edu.cn/faculty/faculty_143.htm. xjduan@pku.edu.cn.
Abstract:
High spatiotemporal resolution interfaces between electrical sensors and biological systems, from single live cells to tissues, is crucial for many areas, including fundamental biophysical studies as well as medical monitoring and intervention. Herein, we summarize recent progress in the development and application of novel nanoscale devices for intracellular electrical recording of action potentials and the effort of merging electronic and biological systems seamlessly in three dimensions by using macroporous nanoelectronic scaffolds. The uniqueness of these nanoscale devices for minimally invasive, large-scale, high spatial resolution, and three-dimensional neural activity mapping are highlighted.
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