Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

The Mitotic Spindle

The Mitotic Spindle

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

The Mitotic Spindle

The Mitotic Spindle

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

Lampbrush Chromosomes

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...

Spindle Assembly

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Determinants of Cardiovascular Events After Simultaneous Pancreas Kidney Transplantation: A Retrospective Cohort Study.

Cureus·2026

Same author

Comment on 'Associations between 12 insulin resistance surrogates with metabolic dysfunction-associated steatotic liver disease risk and all-cause mortality: data from the National Health and Nutrition Examination Survey III (1988-1994)'.

European journal of gastroenterology & hepatology·2026

Same author

Comment on "Localized Tenosynovial Giant Cell Tumors and Indicators of Surgical Recurrence".

Journal of hand surgery global online·2026

Same author

Comment on "optimizing radical cystectomy recovery: The role of modified ERAS in improving postoperative outcomes".

Urologic oncology·2026

Same author

Comment on "Resident Participation in Operative Fixation of Distal Radius Fractures: A Comparison of Outcomes".

Journal of hand surgery global online·2026

Same author

Congenital nephrotic syndrome with fulminant clinical course: A lesson for primary care physician.

Journal of family medicine and primary care·2026

Search research articles

Related Experiment Video

Updated: May 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Spindle cell lipoma.

Nilesh Pardhe¹, Neeraj Singh, Gaurav Bharadwaj

¹Department of Oral and Maxillofacial Pathology, Mahatma Gandhi Dental College & Hospital, Jaipur, Rajasthan, India.

BMJ Case Reports

|August 16, 2013

Summary

This summary is machine-generated.

Spindle cell lipomas (SCLs) are rare benign tumors typically found in older men. This case highlights an unusual SCL presentation in a young boy, emphasizing diagnostic challenges outside typical locations.

More Related Videos

Isolation and Identification of Limbal Niche Cells

Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

Related Experiment Videos

Last Updated: May 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Isolation and Identification of Limbal Niche Cells

Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

Area of Science:

Oncology
Dermatopathology
Medical Imaging

Background:

Spindle cell lipomas (SCLs) are benign lipogenic tumors.
They commonly occur in elderly males on the neck, back, or shoulders.
Atypical locations present diagnostic challenges.

Observation:

A 14-year-old boy presented with a right periorbital mass.
Initial MRI suggested malignancy.
An incisional biopsy led to a preliminary diagnosis of neurofibroma.

Findings:

Histopathological and immunohistochemical analyses confirmed the diagnosis of SCL.
This represents an unusual SCL presentation in a pediatric patient and an atypical location.

Implications:

This case underscores the importance of considering SCLs in unusual locations, even in younger patients.
Accurate diagnosis requires thorough histopathological and immunohistochemical evaluation.
Differentiating SCLs from malignant lesions is crucial for appropriate patient management.