Related Experiment Videos
Nicotinic receptor-mediated catecholamine secretion from individual chromaffin cells. Chemical evidence for
D J Leszczyszyn1, J A Jankowski, O H Viveros
1Department of Chemistry, University of North Carolina, Chapel Hill 27599-3290.
The Journal of Biological Chemistry
|September 5, 1990
Abstract:
Nicotinic receptor-mediated secretion of catecholamines from individual cultured bovine adrenal medullary chromaffin cells was measured and characterized with a voltametric microelectrode placed adjacent to the cells. Nicotine-induced secretion is associated with a large increase in chemical spikes that is temporally resolved into the apparent secretion of discrete packets of attomole quantities of easily oxidized molecules. These data are consistent with direct chemical measurement of single exocytotic events.